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| Laboratory of Molecular NeurosurgeryDirector: Professor Dr. med. Guido Nikkhah, PhD Group Leader: Dr. Máté Döbrössy, PhD |
puplications by Guido Nikkhah> articles > book chapters > books
puplications by Máté Döbrössy
1. Nikkhah G (1989) Medizin mal anders. Dt �rztebl 86 (50):3858-3864. 2. Nikkhah G, Darling JL, Thomas DGT (1989) The application of the MTT chemosensitivity assay to short-term cell lines derived from gliomas: characterization and comparison with a 35S-methionine assay. Reg Cancer Treat 2:112-118. 3. Nikkhah G, Sauer H (1992) Transplantation von Gehirnzellen - Vision oder Realit�t? Dt �rzteblatt 89 (3):106-114. 4. Nikkhah G, Tonn JC, Hoffmann O, Kraemer HP, Darling JL, Sch�nmayr R, Schachenmayr W (1992) The MTT assay for chemosensitivity testing of human tumors of the central nervous system. Part I: Evaluation of test-specific variables. J Neuro Oncol 13 (1):1-11. 5. Nikkhah G, Tonn JC, Hoffmann O, Kraemer HP, Darling JL, Schachenmayr W, Sch�nmayr R (1992) The MTT assay for chemosensitivity testing of human tumors of the central nervous system. Part II: Evaluation of patient- and drug-specific variables. J Neuro Oncol 13 (1):13-24. 6. Cunningham MG, Nikkhah G, McKay RDG (1993) Grafting immortalized hippocampal cells into the brain of the adult and the newborn rat. Neuroprotocols 3: 260-272. 7. Nikkhah G, Duan W-M, Knappe U, J�dicke A, Bj�rklund A (1993) Restoration of complex sensorimotor behavior and skilled forelimb use by a modified nigral cell suspension transplantation approach in the rat Parkinson model. Neuroscience 56 (1):33-43. 8. Nikkhah G, Odin P, Smits A, Tingstr�m A, Othberg A, Brundin P, Funa K, Lindvall O (1993) Platelet-derived growth factor promotes survival of rat and human mesencephalic dopaminergic neurons in culture. Exp Brain Res 92:516-523. 9. Nikkhah G, Sch�nmayr R, V�lkening D, Samii M (1993) Chronic anterior compression of the cervical myelon as a complication of anterior interbody fusion (AIF): Neurological improvement after late anterior decompression. Neurosurg Rev 16: 61-66. 10. Sauer H, Fischer W, Nikkhah G, Wiegand SJ, Brundin P, Lindsay RM, Bj�rklund A (1993) Brain-derived neurotrophic factor enhances function rather than survival of intrastriatal dopamine cell-rich grafts. Brain Res 626:37-44. 11. Tonn JC, Nikkhah G, Darling JL, Schachenmayr W (1993) Test for chemotherapeutic sensitivity of cerebral gliomas: use of the colorimetric MTT assay. J Neurooncol 16 (2):177-180. 12. Nikkhah G, Bentlage C, Cunningham MG, Bj�rklund A (1994) Intranigral fetal dopamine grafts induce behavioral compensation in the rat Parkinson model. J Neurosci 14 (6):3449-3461. 13. Nikkhah G, Cunningham MG, J�dicke A, Knappe U, Bj�rklund A (1994) Improved graft survival and striatal reinnervation using an microtransplantation approach in the rat parkinson model. Brain Research 633:133-143. 14. Nikkhah G, Olsson M, Eberhard J, Bentlage C, Cunningham MG, Bj�rklund A (1994) A microtransplantation approach for cell suspension grafting in the rat Parkinson model. A detailed account of the methodology. Neuroscience 63 (1):57-72. 15. Nikkhah G, Brandis A (1995) Neurotransplantation bei Morbus Parkinson: Experimentelle und klinische Ergebnisse der funktionellen Rekonstruktion des dopaminergen Systems. Zentralbl Neurochirurg 4:153-160. 16. Nikkhah G, Cunningham MG, Cenci MA, McKay R, Bj�rklund A (1995) Dopaminergic microtransplants into the substantia nigra of neonatal rats with bilateral 6-OHDA lesions. I. Evidence for anatomical reconstruction of the nigrostriatal pathway. J Neurosci 15 (5):3548-3561. 17. Nikkhah G, Cunningham MG, McKay R, Bj�rklund A (1995) Dopaminergic microtransplants into the substantia nigra of neonatal rats with bilateral 6-OHDA lesions. II. Transplant-induced behavioral recovery. J Neurosci 15 (5):3562-3570. 18. Nikkhah G, Eberhard J, Olsson M, Bj�rklund A (1995) Preservation of fetal ventral mesencephalic cells by cool storage: In vitro viability and TH-positive neuron survival after microtransplantation to the striatum. Brain Res 687:22-34. 19. Nikkhah G, Samii M (1995) Mikrotransplantation von dopaminergen Gehirnzellen im Tiermodell der Parkinsonschen Erkrankung. Dtsch tier�rztl Wschr 102 (9):371-372. 20. Obermann K, Brandis A, Nikkhah G (1995) Neurotransplantation in Parkinson's disease (news). Lancet 345:443-444. 21. Olsson M, Nikkhah G, Bentlage C, Bj�rklund A (1995) Forelimb akinesia in the rat Parkinson model: differential effects of dopamine agonists and nigral transplants as assessed by a new stepping test. J Neurosci 15 (5):3863-3875. 22. Leanza G, Nikkhah G, Nilsson OG, Wiley RG, Bj�rklund A (1996) Extensive reinnervation of the hippocampus by embryonic basal forebrain cholinergic neurons grafted into the septum of neonatal rats with selective cholinergic lesions. J Comp Neurol 373:355-370. 23. Leanza G, Nilsson OG, Nikkhah G, Wiley RG, Bj�rklund A (1996) Effects of neonatal lesions of the basal forebrain cholinergic system by 192 IgG-saporin: biochemical, behavioral and morphological characterization. Neuroscience 74:119-141. 24. L�scher W, Richter A, Nikkhah G, Rosenthal C, Ebert U, Hedrich H-J (1996) Behavioral and neurochemical dysfunction in the circling (ci) rat: a novel genetic animal model of a movement disorder. Neuroscience 74:1135-1142. 25. Carvalho GA, Nikkhah G, Matthies C, Penkert G, Samii M (1997) Diagnosis of root avulsions in traumatic brachial plexus injuries. The value of computerized tomography myelo graphy and magnetic resonance imaging. J Neurosurg 86:69-76. 26. Carvalho GA, Nikkhah G, Samii M (1997) Preoperative diagnosis and surgical indication in traumatic injuries of the brachial plexus. Orthop�de, 26:599-605. 27. Carvalho GA, Nikkhah G, Samii M (1997) Treatment of pain following traumatic lesions of the brachial plexus. Orthop�de 26:621-625. 28. Nikkhah G, Carvalho CA, Samii M (1997) Neurotization for restoration of arm function in complete cervial root avulsion. Orthop�de 26:606-611. 29. Nikkhah G, Carvalho GA, Samii M (1997) Autologous transplantation and neurolysis of the brachial plexus following trauma. Orthop�de 26:612-620. 30. Rohlfs A, Nikkhah G, Rosenthal C, Rundfeldt C, Brandis A, Samii M, L�scher W (1997) Hemispheric asymmetries in spontaneous firing characteristics of substantia nigra pars reticulata neurons following a unilateral 6-hydroxydopamine lesion of the rat nigrostriatal pathway. Brain Res 761:352-356. 31. Samii M, Carvalho GA, Nikkhah G, Penkert G (1997) Surgical reconstruction of the musculocutaneus nerve in traumatic brachial plexus injuries. J Neurosurg 87:881-886. 32. Brandis A, Kuder H, Knappe U, J�dicke A, Sch�nmayr R, Samii M, Walter GF, Nikkhah G (1998) Time-dependent expression of donor- and host-specific major histocompatibility complex class I and II antigens in allogeneic dopamine-rich macro- and micrografts: comparison of two different grafting protocols. Acta Neuropathol, 95: 85-97. 33. L�scher W, Ebert U, Lehmann H, Rosenthal C, Nikkhah G (1998) Seizure suppression in kindling epilepsy by grafts of gabaergic neurons in rat substantia nigra. J Neurosci Res, 51:196-209. 34. Nikkhah G, Rosenthal C, Falkenstein G, Samii M (1998) Dopaminergic graft-induced long-term recovery of complex sensorimotor behaviors in a rat model of Parkinson's disease. Zentrbl Neurochir, 59: 97-103. 35. Nikkhah G, Rosenthal C, Hedrich H, Samii M (1998) Differences in acquisition and full performance in skilled forelimb use as measured by the staircase test in five rat strains. Beh Brain Res, 92: 85-95. 36. Bentlage C., Nikkhah G., Cunningham M. G. and Bj�rklund A. (1999) Reformation of the nigrostriatal pathway by fetal dopaminergic micrografts into the substantia nigra is critically influenced by the age of the host. Exp Neurol 159, 177-190. 37. Defer G., Widner, H., Mari� R., R�my P., Levivier M. and Conference Participants (Nikkhah G., et al.) (1999) Core Assessment Program for Surgical Interventional Therapies in Parkinson's Disease (CAPSIT-PD). Mov. Disord. 14, 572-584. 38. Penkert G., Carvalho G. A., Nikkhah G., Tatagiba M., Matthies C. and Samii, M. (1999) Diagnosis and surgery of brachial plexus injuries. J Reconstr Microsurg 15, 3-8. 39. Winkler C., Bentlage C., Nikkhah G., Samii M. and Bj�rklund A. (1999) Intranigral transplants of GABA-rich striatal tissue induce behavioral recovery in the rat parkinson model and promote the effects obtained by intrastriatal dopaminergic transplants. Exp Neurol 155, 165-186. 40. R�dter A., Winkler C., Samii M. and Nikkhah G. (2000) Complex sensorimotor behavioral changes after terminal striatal 6-OHDA lesion and transplantation of dopaminergic embryonic micrografts. Cell Transplantation 9, 197-214. 41. R�dter A., Winkler C., Samii M., Walter G.F., Brandis A. and Nikkhah G. (2001) A comparison of uni- versus bilateral intrastriatal 6-OHDA-induced axon terminal lesions: Evidence for interhemispheric coupling of the two nigrostriatal pathways. J Comp Neurol, 432, 217-229. 42. Brundin P, Dunnett SB, Bj�rklund A and Nikkhah G (2001) Transplanted dopaminergic neurons: More or less? Nature Med 7 (5), 512-513. 43. Nikkhah G, Falkenstein G and Rosenthal C (2001) Restorative plasticity of dopamine neuronal transplants depends on the degree of hemispheric dominance. J Neurosci, 21 (16), 6252-6263. 44. Carvalho GA and Nikkhah G (2001) Subthalamic nucleus lesions are neuroprotective against terminal 6-OHDA-induced striatal lesions and restore postural balancing reactions. Exp Neurol, 171(2), 405-17. 45. Berding G, Odin P, Brooks D, Nikkhah G, Matthies C, Peschel T, Shing M, Kolbe H, Hoff J, Fricke H, Dengler R, Samii M, Knapp W (2001) Glucose metabolism in advanced Parkinson�s disease studied during �off� and �on� condition using (18F)FDG-PET. Mov Disord, 16(6), 1014-22. 46. Grothe C and Nikkhah G (2001) The role of basic fibroblast growth factor (FGF-2) in peripheral nerve regeneration. Anat Embrol, 204(3), 171-7. 47. Nikkhah G (2001) Transplantation of embryonic dopamine neurons for severe Parkinson�s disease: Potential and Pitfalls. Brain Res Bull, 56(6), 509. 48. Winkler C, Bentlage C, Cenci, MA, Nikkhah G, Bj�rklund A (2003) Regulation of neuropeptide mRNA expression in the basal ganglia by intrastriatal and intranigral transplants in the rat Parkinson model. Neuroscience, 118(4):1063-77. 49. Just L, Timmer M, Tinius J, Stahl F, Deiwick A, Nikkhah G, Bader A (2003) Identification of human cells in brain xenografts and in neural co-culture of rat by in situ hybridisation with Alu probe. J Neurosci Methods, 126(1), 69-77. 50. Timmer M, Robben S, M�ller-Ostermeyer F, Nikkhah G, Grothe C (2003) Axonal regeneration across long gaps in silicone chambers filled with Schwann cells overexpressing high molecular weight FGF-2. Cell Transplant 12(3), 265-77. 51. Nikkhah G., Prokop T., Hellwig B., Lucking C.H., and Ostertag C.B. (2004) Deep brain stimulation of the nucleus ventralis intermedius for Holmes (rubral) tremor and associated dystonia caused by upper brainstem lesions. Report of two cases. J. Neurosurg. 100, 1079-1083. 52. Timmer M., Mueller-Ostermeyer F., Kloth V., Winkler C., Grothe C., and Nikkhah G. (2004) Enhanced survival, reinnervation, and functional recovery of intrastriatal dopamine grafts co-transplanted with Schwann cells overexpressing high molecular weight FGF-2 isoforms. Exp. Neurol. 187, 118-136. 53. Grothe C., Timmer M., Scholz T., Winkler C., Nikkhah G., Claus P., Itoh N., and Arenas E. (2004) Fibroblast growth factor-20 promotes the differentiation of Nurr1-overexpressing neural stem cells into tyrosine hydroxylase-positive neurons. Neurobiol. Dis. 17, 163-170. 54. Lutterbach J, Pagenstecher A, Spreer J, Hetzel A, Velthoven VV, Nikkhah G, Frommhold H, Volk B, Schumacher M, Lucking C, Zentner J, Ostertag C (2004) The Brain Tumor Board: Lessons to Be Learned from an Interdisciplinary Conference. Onkologie 28. 55. Nikkhah, G. (2005) Stammzellbasierte Rekonstruktion des dopaminergen Projektionssystems: Von der Molekularbiologie zur klinischen Anwendung beim Morbus Parkinson. Neuroforum 04/05:120-127. 56. Hahn M., Timmer M., and Nikkhah G. (2006) Distinctive pattern of anatomical maturation and functional integration of dopaminergic progenitor cells following transplantation in a rat model of Parkinson's disease. The Journal of Comparative Neurology. Resubmitted. 57. Kloth V., Klein A., Loettrich D., and Nikkhah G. (2006) Colour-coded pellets increase the sensitivity of the staircase test to differentiate skilled forelimb performances of normal and 6-Hydroxydopamine lesioned rats. Brain Res Bull. Jun 15;70(1):68-80.
1. Tonn J-C, Nikkhah G, Roosen K, Schachenmayr W (1992) MTT assay for in vitro chemosensitivity testing of malignant intracranial tumors. In: Advances in Neurosurgery (Piscol K. KM Brock M., eds.), 20, pp 281-285. Berlin: Springer. 2. Bj�rklund A, Dunnett SB, Nikkhah G (1994) Nigral transplants in the rat Parkinson model: Functional limitations and strategies to enhance nigrostriatal reconstruction. In: Functional Neural Transplantation (Dunnett SB and Bj�rklund A, eds.), Advances in Neuroscience, 2, pp 47-70. New York: Raven Press. 3. Knappe U, Brandis A, J�dicke A, Walter GF, Samii M, Sch�nmayr R, Nikkhah G (1994) Allogeneic neurografting in the rat model of Parkinson's disease: effect of the grafting technique on the functional and morphlogical integration of the transplant. In: Advances in Neurosurgery (Bauer B.L., Brock M., Klinger M., eds.), 22, pp 313-317. Berlin: Springer. 4. Penkert G, Carvalho GA, Nikkhah G, Samii M (1996) Reinnervation bei Wurzelausrissen des PLexus brachialis miitels des N. accessorius als Spendernerv. Kongre�band zur 33 Jahrestagung der Deutschen Gesellschaft f�r Plastische und Wiederherstellungschirurgie, pp 468-470. 5. Samii M, Nikkhah G, Carvalho GA, Penkert G (1996) Periphere Nerventransplantation zur Rekonstruktion des N. musculocutaneus bei traumatischen Armplexus-L�sionen. Kongre�band zur 33 Jahrestagung der Deutschen Gesellschaft f�r Plastische und Wiederherstellungschirurgie, pp 464-465. 6. Samii M, Carvalho GA, Nikkhah G, Penkert G (1996) Neurotization des Plexus brachialis: Interkostalnervenanastomose mit dem N. musculocutaneus. Kongre�band zur 33 Jahrestagung der Deutschen Gesellschaft f�r Plastische und Wiederherstellungschirurgie, pp 471-472. 7. Samii M, Tatagiba M, Nikkhah G, Carvalho GA, Penkert G (1996) Zur funktionellen Rekonstruktion des N. axillaris bei traumatischen Armplexus-L�sionen. Kongre�band zur 33 Jahrestagung der Deutschen Gesellschaft f�r Plastische und Wiederherstellungschirurgie, pp 466-467. 8. Schuhmann M, Nikkhah G, L�demann W, Carvalho GA, Matthies C, Penkert G, Samii M (1996) Die Behandlung traumatischer L�sionen des N. ulnaris: Indikationen, Technik und Ergebnisse. Kongre�band zur 33 Jahrestagung der Deutschen Gesellschaft f�r Plastische und Wiederherstellungschirurgie, pp 462-463. 9. Nikkhah G and Samii M (1998) Principles of neural transplantation in the central nervous system. In: Hellwig and Bauer (eds) Minimally Invasive Techniques for Neurosurgery, Springer, Heidelberg, pp 257-266. 10. Nikkhah, G., Winkler, C., R�dter, A. and Samii, M. (2000) Microtransplantation of nigral dopamine neurons: A "step-by-step" recipe, in NeuroMethods: Cell and Tissue Transplantation in the CNS (S. B. Dunnett and G. Baker, eds.), Humana Press Inc., Totowa, N.J., pp 207-231. 11. Samii, M., Nikkhah, G. and Carvalho, G. A. (2001) Operative Versorgung peripherer Nervenl�sionen, in Praxis der Orthop�die (C. J. Wirth, eds.), Georg Thieme Verlag, Stuttgart-New York, pp. 117-129 . 12. Feuerstein, T.J. and Nikkhah, G. (2003) Antiparkinson Drugs, in Enclyclopedic Reference of Molecular Pharmacology (Offermanns, eds.), 101-106.
1. Nikkhah G (1990) Humanmedizin in Gie�en. Gie�en: JF Lehmanns, pp 133. 2. Nikkhah G (1991) Studium der Humanmedizin. Stuttgart: Georg Thieme Verlag, pp 142. 3. Nikkhah G (1994) Microtransplantation of Nigral Dopamine Neurons in a Rat Model of Parkinson's Disease. PhD thesis, Lund: Grahns, pp 208. 4. Brandis A, Nikkhah G, Obermann K (1995) Brennpunkt - Neurotransplantation. Sonderheft Zentralblatt f�r Neurochirurgie, Bock WJ (ed.), Heidelberg: Johann Ambrosius Barth Verlag 4/95, pp 73. 1. Döbrössy MD, Svendsen CN, and Dunnett SB (1995). Effects of Bilateral Striatal Lesions on the Acquisition of an Operant Working Memory Task. NeuroReport 6, 15: 2049-2053. 2. Döbrössy MD Svendsen CN, and Dunnett SB (1996). Bilateral striatal lesions impair retention of an operant test of short-term memory. Brain Res Bull, 41, 3: 159-165. 3. Döbrössy MD and Dunnett SB (1997). Unilateral striatal lesions impair response execution on a lateralised choice reaction time task. Behav Brain Res, 87: 159-171. 4. Brasted PJ, Döbrössy MD and Dunnett SB (1998). Striatal lesions produce impairements in reaction time performance in two different operant chambers. Brain Res Bull, 46, 6: 487-493. 5. Döbrössy MD and Dunnett SB (1999). Striatal grafts alleviate deficits in response execution in a lateralised reaction time task. Brain Res Bull, 47(6): 585-593. 6. Brasted PJ, Döbrössy MD, Eagle DM, Nathwani F, Robbins TW, and Dunnett SB (2000). Operant analysis of striatal dysfunction. In: Central Nervous System Diseases: Innovative animal models from Lab to Clinic. (Eds. Emerich, DF, Dean, RL and Sandberg, PR). Humana Press, 249-273. 7. Döbrössy MD, Le Moal M, Monatron MF, and Abrous, DN (2000). Influence of the environment on the efficacy of intrastriatal dopaminergic grafts. Exp Neurol, 164, 165-172. 8. Döbrössy MD and Dunnett SB (2001). The influence of environment and experience on neural grafts. Nature Reviews Neurosci, 2, 12: 871-879. 9. Döbrössy MD and Dunnett SB (2002). Functional repair of the striatum with striatal grafts. Acta Phys Hungarica, 89,1-3, 207. 10. Döbrössy MD, Chapman PF, and Dunnett SB (2002). Striatal graft: electrophysiological investigation of synaptic plasticity and circuit reconstruction. Exp Neurol, 175 (2), 445. 11. Döbrössy MD and Dunnett SB (2003). Motor training effects on recovery of function after striatal lesions and striatal grafts. Exp Neurol, 184 (1), 274-284. 12. Döbrössy MD, Drapeau E, Aurousseau C, Le Moal M, Piazza PV, and Abrous DN (2003). Differential effects of learning on neurogenesis: learning increases or decreases the number of newly born cells depending on their birth date. Mol Psych, 8, 974-982. doi:10.1038/sj.mp.4001419 13. Döbrössy MD and Dunnett SB (2004). Environmental enrichment affects striatal graft morphology and functional recovery. Eur J Neurosci, 19, 159-168. 14. Döbrössy MD and Dunnett SB (2005). Optimising plasticity: Environmental and training associated factors in transplant-mediated brain repair. Reviews in the Neurosciences, 16, 1-21. 15. Döbrössy MD and Dunnett SB (2005). Training specificity, graft development and graft mediated functional recovery in a rodent model of Huntington‘s disease. Neuroscience, 132, 543-552 . 16. Döbrössy MD and Dunnett SB (2005). Plasticity, Cell Transplantation and Brain Repair. In: Synaptic Plasticity: Basic Mechanisms to Clinical Applications. (Eds. Baudry, M., Bi, X., Schreiber, S.), Taylor & Francis. 17. Jones-Mazzocchi D, Döbrössy MD and Dunnett SB (2005). Striatal grafts and synaptic plasticity. In: Basal Ganglia VIII (eds. Bolam, J.Paul; Ingham, Cali A.; Magill, Peter J.). London. 18. Döbrössy MD and Dunnett SB (2006). The effects of lateralised training on spontaneous forelimb preference, lesion deficits and graft mediated functional recovery after unilateral striatal lesions in rats. Exp Neurol, 199(2): 373-383. 19. Sloan HL, Döbrössy MD, Dunnett SB (2006). Hippocampal lesions impair performance on a conditional delayed matching and non-matching to position task in the rat. Behav Brain Res, 171(2): 240-250. 20. Döbrössy MD and Dunnett SB (2006). Morphological and cellular changes within embryonic striatal grafts associated with enriched environment and involuntary exercise. Eur.J Neurosci. 24: 3223-3233. 21. Döbrössy MD and Dunnett SB (2007). The Corridor task: Striatal lesion effects and graft-mediated recovery in a model of Huntington‘s disease. Behav. Bra. Res., doi:10.1016/j.bbr. 2007.02.030 22. Dupret D, Rodriguez JJ, Döbrössy MD, Aurousseau C, Stewart MG, Piazza PV and Abrous DN (2007). Spatial learning depends on both the addition and removal of new hippocampal neurons. PLoS Biol 5(8): 1683-1694. e214: doi:10.1371/journal.pbio.0050214. 23. Döbrössy MD and Dunnett SB (2008). Environmental housing and duration of exposure affect striatal graft morphology in a rodent model of Huntington‘s disease. Cell Transpl., accepted for publication. 24. Döbrössy MD, Brooks S, Trueman R, Brasted PJ and Dunnett SB (2008). Operant Analysis of Fronto-striatal Function in Rodents. In: Methods of Behaviour Analysis in Neuroscience (Ed. Buccafusco, J.), CRC Press, in press. 25. Cunha C, Angelucci A, D‘Antoni A, Döbrössy MD, Dunnett SB, Berardi N and Brambilla R (2008). Brain-Derived Neurotrophic Factor (BDNF) over-expression in the forebrain results in learning and memory impairments. Neurobiology of Disease, submitted. 26. Jones-Mazzocchi D, Döbrössy MD and Dunnett SB (2008). Embryonic Striatal Grafts Display Bidirectional Plasticity. In preparation for submission to Brain. |
